Book description
The chemistry of heterocycles is an important branch of organic
chemistry. This is due to the fact that a large number of natural
products, e. g.
hormones, antibiotics, vitamins, etc. are composed of heterocyclic
structures. Often, these compounds show beneficial properties and are
therefore applied as pharmaceuticals to treat diseases or as
insecticides, herbicides or fungicides in crop protection.
This volume presents important pharmaceuticals. Each of the 20 chapters
covers in a concise manner one class of heterocycles, clearly
structuredas follows:
* Structural formulas of most important examples (market products)
* Short background of history or discovery
* Typical syntheses of important examples
* Mode of action
* Characteristic biological activity
* Structure-activity relationship
* Additional chemistry information (e. g. further transformations,
alternative syntheses, metabolic pathways, etc.)
* References.
A valuable one-stop reference source for researchers in academia and
industry as well as for graduate students with career aspirations in the
pharmaceutical chemistry. Jürgen Dinges obtained his M. S. degree in
organic chemistry at the Technical University in Darmstadt, Germany in
1988. He then joined the group of Prof. Frieder W. Lichtenthaler at the
same University, where he received his Ph. D. degree in organic
chemistry and chemical engineering in 1991. After being awarded a
Feodor-Lynen scholarship from the Humboldt foundation, he spent 18
months as a postdoctoral fellow in the group of Prof. William G. Dauben
at the University of California at Berkeley, U. S.A. In 1993, Jurgen
Dinges joined the department for biochemistry at Syntex, U. S.A. and
since 1995 he is working in the pharmaceutical research department at
Abbott Laboratories, U. S.A. In 2009, he was a guest editor for Current
Topics in Medicinal Chemistry for a special issue on Parkinson's
disease. He is an author of 17 publications and 23 patents and a
co-inventor of more than 10 clinical drug development candidates.
Clemens Lamberth is a senior team leader in the crop protection research
department of Syngenta AG, Switzerland. He studied chemistry at the
Technical University of Darmstadt, Germany, where he obtained his Ph. D.
under the supervision of Prof. Bernd Giese in 1990. Subsequently, he
spent one and a half years as a postdoctoral fellow in the group of
Prof. Mark Bednarski at the University of California at Berkeley, U.
S.A. In 1992 Clemens Lamberth joined the agrochemical research
department of Sandoz Agro AG, Switzerland, which is today, after two
mergers, part of Syngenta Crop Protection AG. Since 20 years he is
specialized in fungicide discovery. He was the organizer of the two-day
session 'New Trends for Agrochemicals' at the 2nd EUCHEMS congress in
Torino 2008. He is the author of 46 publications and 56 patents and the
inventor of Syngenta's fungicide mandipropamid (Revus?, Pergado?).
