Book description
Unlike other handbooks in this emerging field, this guide focuses on
the challenges and critical parameters in running a metabolomics study,
including such often-neglected issues as sample preparation, choice of
separation and detection method, recording and evaluating data as well
as method validation. By systematically covering the entire workflow,
from sample preparation to data processing, the insight and advice
offered here helps to clear the hurdles in setting up and running a
successful analysis, resulting in high-quality data from every experiment.
Based on more than a decade of practical experience in developing,
optimizing and validating metabolomics approaches as a routine
technology in the academic and industrial research laboratory, the
lessons taught here are highly relevant for all systems-level
approaches, whether in systems biology, biotechnology, toxicology or
pharmaceutical sciences.
Michael Lammerhofer is Associate Professor at the Department of
Analytical Chemistry of the University of Vienna (Austria). Having
obtained his academic degrees from the University of Graz, he spent two
years as a post-doctoral fellow at the Department of Chemistry of the
University of California, Berkeley (USA). His current research is
directed towards the targeted quantitative analysis of extracellular and
intracellular metabolites, mainly with focus on applications in
industrial biotechnology.
Wolfram Weckwerth is Full Professor and Head of the Department of
Molecular Systems Biology at the University of Vienna (Austria). Having
obtained his academic degrees from the Technical University of Berlin
(Germany), he moved to the Max-Planck-Institute of Molecular Plant
Physiology, where he pioneered metabolomic methods and integrated
proteomic and computer-based approaches into a systems biology
framework. After his habilitation in Systems Biology at the University
of Potsdam, he took over a position as a head of a research lab in the
German FORSYS systems biology initiative, before founding the Department
of Molecular Systems Biology at the University of Vienna in 2008.
