Book description
With its content stemming from tried and tested course notes, this book
draws on the expertise from authors based at leading pharmaceutical
companies such as Bayer, AstraZeneca and Novartis, as well as leading
academic institutions. As such, it represents the perfect blend of
theoretical background and application-oriented discussions, including
the latest research developments and industrial examples.
In the first section, the basic mechanisms are introduced, ensuring an
understanding of supersaturation. In addition, the solubility of the
substance and its dependences on process conditions and the various
techniques of crystallization and their possibilities and limitations
are discussed. The second part builds on the basics, exploring how
crystallization processes can be developed, either batch-wise or
continuous, from solution or from the melt. The two sections are bridged
by a discussion of the purification during crystallization, where
practical aspects and an insight using theoretical concepts are
combined. The third part of the book is dedicated to accounts of actual
developments and successful crystallizations, outlining typical pitfalls
and strategies to avoid them, as well as to the design of robust processes.
Wolfgang Beckmann is Senior Scientist at Bayer Technologies. Dr.
Beckmann studied Chemical Engineering and Physical Chemistry in Germany
and the US. He spent one year as Postdoctoral Fellow in Marseille.
Wolfgang Beckmann has spent the last 20 years working at Bayer and prior
to this at Schering, developing crystallization processes for
pharmaceutical compounds. He has authored 3 chapters in books and
approximately 50 publications in reviewed journals.
