Book description
Small structural modifications can significantly affect the
pharmacokinetic properties of drug candidates. This book, written by a
medicinal chemist for medicinal chemists, is a comprehensive guide to
the pharmacokinetic impact of functional groups, the pharmacokinetic
optimization of drug leads, and an exhaustive collection of
pharmacokinetic data, arranged according to the structure of the drug,
not its target or indication. The historical origins of most drug
classes and general aspects of modern drug discovery and development are
also discussed. The index contains all the drug names and synonyms to
facilitate the location of any drug or functional group in the book.
This compact working guide provides a wealth of information on the ways
small structural modifications affect the pharmacokinetic properties of
organic compounds, and offers plentiful, fact-based inspiration for the
development of new drugs. This book is mainly aimed at medicinal
chemists, but may also be of interest to graduate students in chemical
or pharmaceutical sciences, preparing themselves for a job in the
pharmaceutical industry, and to healthcare professionals in need of
pharmacokinetic data. Florencio Zaragoza Dorwald studied chemistry at
the Georg-August University in Gottingen, Germany, and Universite
LouisPasteur, Strasbourg, France, where he obtained his Ph. D. in 1990
on the synthesis of natural products under the guidance of M.
Franck-Neumann and M. Miesch. He spent one postdoctoral year in both the
groups of A. Pfaltz (University of Basel) and A. P. Marchand (University
of North Texas), and then worked on the synthesis of unnatural amino
acids at the Technical University of Dresden. From 1994 to 2007 he had a
position as
a medicinal chemist at Novo Nordisk A/S, Denmark. Currently, he is
employed as organic chemist at Lonza AG in Visp, Switzerland.
