Book description
In this ground-breaking practical reference, the family of aspartic
acid proteases is described from a drug developer's perspective. The
first part provides a general introduction to the family of aspartic
acid proteases, their physiological functions, molecular structure and
inhibition. Parts two to five present various case studies of successful
protease inhibitor drug design and development, as well as current and
potential uses of such inhibitors in pharmaceutical medicine, covering
the major therapeutic targets HIV-1 protease, renin, beta-secretase,
gamma-secretase,plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in the pharmaceutical
industry, as well as for anyone studying proteases and their function.
Arun K. Ghosh studied chemistry at the University of Calcutta and the
Indian Institute of Technology, Kanpur. He obtained his Ph. D. at the
University of Pittsburgh and pursued post-doctoral research at Harvard
University. He was a research fellow at Merck Research Laboratories
prior to joining the University of Illinois, Chicago as an assistant
Professor in 1994. In 2005, he moved to Purdue University where he is
currently the Ian P. Rothwell Distinguished Professor of Chemistry and
Medicinal Chemistry. His notable honors include, Arthur C. Cope Scholar
Award, Robert Scarborough Medicinal Chemistry Award, American
Association for the Advancement of Science, University of Illinois
University Scholar, National Merit Scholar of India. He has published
over 200 research papers and holds numerous patents. Professor Ghosh's
research interests include diverse areas of organic, bioorganic and
medicinal chemistry with particular emphasis on organic synthesis and
protein-structure-based design of biomolecules.
