Book description
By way of its clear and logical structure, as well as abundant
highresolution illustrations, this is a systematic survey of the players
and pathways that control genome function in the mammalian cell nucleus.
As such, this handbook and reference ties together recently gained
knowledge from a variety of scientific disciplines and approaches,
dissecting all major genomic events: transcription, replication, repair,
recombination and chromosome segregation. A special emphasis is put on
transcriptional control, including genome-wide interactions and
non-coding RNAs, chromatin structure, epigenetics and nuclear
organization.
With its focus on fundamental mechanisms and the associated
biomolecules, this will remain essential reading for years to come.
Karsten Rippe leads the Research Group Genome Organization &
Function at the German Cancer Research Center and the BioQuant Institute
in Heidelberg, Germany. In his research, he combines molecular/cell
biology and physics to quantitatively investigate and model the relation
between nuclear DNA organization and cell function. Karsten Rippe has
obtained his academic degrees from the University of
Gottingen while working at the Max Planck Institute for Biophysical
Chemistry and continued his scientific career at the University of
Oregon in Eugene and the Kirchhoff-Institut fur Physik in Heidelberg. He
has authored more than 80 scientific publications in the fields of DNA
structure, transcription and chromatin and has received several
scientific awards, including the Otto Hahn medal of the Max Planck
Society and the European Beckman DNA Award.
