Book description
This is the third of five books in the Amino Acids, Peptides and
Proteins in Organic Synthesis series.
Closing a gap in the literature, this is the only series to cover
this important topic in organic and biochemistry. Drawing upon the
combined expertise of the international "who's who" in amino
acid research, these volumes represent a real benchmark for amino acid
chemistry, providing a comprehensive discussion of the occurrence,
uses and applications of amino acids and, by extension, their
polymeric forms, peptides and proteins.
The practical value of each volume is heightened by the inclusion of
experimental procedures.
The 5 volumes cover the following topics:
Volume 1: Origins and Synthesis of Amino Acids
Volume 2: Modified Amino Acids, Organocatalysis and Enzymes
Volume 3: Building Blocks, Catalysis and Coupling Chemistry
Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis
Volume 5: Analysis and Function of Amino Acids and Peptides
This third volume in the series presents an in depth account of
recent developments in the (bio-)synthesis of amino acids and
peptides. Divided into two parts, the first section deals with amino
acids as building blocks, including the generation of alpha-amino
acids, beta-lactams, and heterocycles. The second section is devoted
to the synthesis of peptides, with the focus on solid phase synthesis.
However, solution phase peptide synthesis is covered as well, as are
topics such as coupling reagents, chemical ligation, peptide
purification and automation.
Originally planned as a six volume series, Amino Acids, Peptides
and Proteins in Organic Chemistry now completes with five
volumes but remains comprehensive in both scope and coverage.
Further
information about the 5 Volume Set and purchasing details can be
viewed here.
Andrew Hughes
is a reader and associate professor of chemistry at La Trobe
University, Melbourne, Australia. He obtained his degrees from the
University of Western Australia, before taking up post-doctoral
appointments at the University of Cambridge starting in 1989. After
three years working with Professor Andrew Holmes, he joined Professor
Steven Ley`s group. While at Cambridge he was appointed the Shell
Research Fellow at Robinson College. His interests lie in the general
field of asymmetric synthesis and methodology, with a recent focus on
amino acid chemistry and difficult peptides.
