Book description
Chemokines are hormone-like signaling molecules secreted by cells to
signal infection and guide the immune response. Following a decade of
basic chemokine research, the pharmaceutical industry has now begun to
exploit this crucial signaling pathway for the development of innovative
drugs against AIDS, cancer, neural and autoimmune diseases. Here is the
first reference focusing on these novel drug development opportunities.
Opening with a general introduction on chemokine function and chemokine
receptor biology, the second part covers the known implications of these
signaling molecules in human diseases, such as cancer, neural disorders,
and viral infection, including AIDS. The third part systematically
surveys current drug development efforts at targeting individual
chemokine receptors, as well as other chemokine interaction partners,
including up-to-date reports from the pharmaceutical industry.
The editors are based at the Amsterdam Center for Drug Research, a
cross-disciplinary center in the Dutch academic system, but with
numerous ties to pharmaceutical companies.
