Book description
Most textbooks on neurodegenerative disorders have used a
classification scheme based upon either clinical syndromes or anatomical
distribution of the pathology. In contrast, this book looks to the
future and uses a classification based upon molecular mechanisms, rather
than clinical or anatomical boundaries. Major advances in molecular
genetics and the application of biochemical and immunocytochemical
techniques to neurodegenerative disorders have generated this new
approach. Throughout most of the current volume, diseases are clustered
according to the proteins that accumulate within cells (e. g. tau,
α-synuclein and TDP-43) and in the extracellular compartments (e. g.
β-amyloid and prion proteins) or according to a shared pathogenetic
mechanism, such as trinucleotide repeats, that are a feature of specific
genetic disorders. Chapters throughout the book conform to a standard
lay-out for ease of access by the reader and are written by a panel of
International Experts
Since the first edition of this book, major advances have been made
in the discovery of common molecular mechanisms between many
neurodegenerative diseases most notably in the frontotemporal lobar
degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis.
This book will be essential reading for clinicians, neuropathologists
and basic neuroscientists who require the firm up-to-date knowledge of
mechanisms, diagnostic pathology and genetics of Neurodegenerative
diseases that is required for progress in therapy and management.
