Book description
The field of solid state characterization is central to the
pharmaceutical industry, as drug products are, in an overwhelming number
of cases, produced as solid materials. Selection of the optimum solid
form is a critical aspect of the development of pharmaceutical
compounds, due to their ability to exist in more than one form or
crystal structure (polymorphism). These polymorphs exhibit different
physical properties which can affect their biopharmaceutical properties.
This book provides an up-to-date review of the current techniques
used to characterize pharmaceutical solids. Ensuring balanced,
practical coverage with industrial relevance, it covers a range of key
applications in the field.
The following topics are included:
- Physical properties and processes
- Thermodynamics
- Intellectual guidance
- X-ray diffraction
- Spectroscopy Microscopy
- Particle sizing
- Mechanical properties
- Vapour sorption
- Thermal analysis & Calorimetry
- Polymorph prediction
- Form selection
Richard A. Storey, AstraZeneca Pharmaceuticals,
Macclesfield, UK
Ingvar Ymén, AstraZeneca R&D, Södertälje, Sweden
