Book description
One approach to organic synthesis is retrosynthetic analysis. With this
approach chemists start with the structures of their target molecules
and progressively cut bonds to create simpler molecules. Reversing this
process gives a synthetic route to the target molecule from simpler
starting materials. This “disconnection” approach to synthesis is now a
fundamental part of every organic synthesis course.
Workbook for Organic Synthesis: The Disconnection Approach,
2nd Edition
This workbook provides a comprehensive graded set of problems to
illustrate and develop the themes of each of the chapters in the
textbook Organic Synthesis: The Disconnection Approach,
2nd Edition. Each problem is followed by a fully
explained solution and discussion. The examples extend the student's
experience of the types of molecules being synthesised by organic
chemists, and the strategies they employ to control their syntheses.
By working through these examples students will develop their skills
in analysing synthetic challenges, and build a toolkit of strategies
for planning new syntheses. Examples are drawn from pharmaceuticals,
agrochemicals, natural products, pheromones, perfumery and flavouring
compounds, dyestuffs, monomers, and intermediates used in more
advanced synthetic work. Reasons for wishing to synthesise each
compound are given. Together the workbook and textbook provide a
complete course in retrosynthetic analysis.
Organic Synthesis: The Disconnection Approach, 2nd Edition
There are forty chapters in Organic Synthesis: The Disconnection
Approach, 2nd Edition: those on the synthesis of
given types of molecules alternate with strategy chapters in which the
methods just learnt are placed in a wider context. The synthesis
chapters cover many ways of making each type of molecule starting with
simple aromatic and aliphatic compounds with one functional group and
progressing to molecules with many functional groups. The strategy
chapters cover questions of selectivity, protection, stereochemistry,
and develop more advanced thinking via reagents specifically designed
for difficult problems. In its second edition updated examples and
techniques are included and illustrated additional material has been
added to take the student to the level required by the sequel,
Organic Synthesis: Strategy and Control. Several chapters
contain extensive new material based on courses that the authors give
to chemists in the pharmaceutical industry.
Workbook for Organic Synthesis: The Disconnection Approach,
2nd edition, combined with the main textbook,
provides a full course in retrosynthetic analysis for chemistry and
biochemistry students, and a refresher course for organic chemists
working in industry and academia.
