Book description
One approach to organic synthesis is retrosynthetic analysis. With this
approach a chemist will start with the structure of their target
molecule and progressively cut bonds to create simpler molecules.
Reversing this process gives a synthetic route to the target molecule
from simpler starting materials. This “disconnection” approach to
synthesis is now a fundamental part of every organic synthesis course.
Organic Synthesis: The Disconnection Approach, 2nd
Edition introduces this important technique, to help students
to design their own organic syntheses. There are forty chapters: those
on the synthesis of given types of molecules alternate with strategy
chapters in which the methods just learnt are placed in a wider
context. The synthesis chapters cover many ways of making each type of
molecule starting with simple aromatic and aliphatic compounds with
one functional group and progressing to molecules with many functional
groups. The strategy chapters cover questions of selectivity,
protection, stereochemistry, and develop more advanced thinking via
reagents specifically designed for difficult problems.
Examples are drawn from pharmaceuticals, agrochemicals, natural
products, pheromones, perfumery and flavouring compounds, dyestuffs,
monomers, and intermediates used in more advanced synthetic work.
Reasons for wishing to synthesise each compound are given.
This second edition has been fully revised and updated with a modern
look. Recent examples and techniques are included and illustrated
additional material has been added to take the student to the level
required by the sequel, “Organic Synthesis: Strategy and Control”.
Several chapters contain extensive new material based on courses that
the authors give to chemists in the pharmaceutical industry.
Organic Synthesis: The Disconnection Approach, 2nd
edition provides a full course in retrosynthetic analysis for
chemistry and biochemistry students and a refresher for organic
chemists working in industry and academia.
