Book description
Chitosan is a linear polysaccharide commercially produced by the
deacetylation of chitin. It is non-toxic, biodegradable, biocompatible,
and acts as a bioadhesive with otherwise unstable biomolecules - making
it a valuable component in the formulation of biopharmaceutical drugs.
Chitosan-Based Systems for Biopharmaceuticals provides an
extensive overview of the application of chitosan and its derivatives
in the development and optimisation of biopharmaceuticals. The book is
divided in four different parts. Part I discusses general aspects of
chitosan and its derivatives, with particular emphasis on issues
related to the development of biopharmaceutical chitosan-based
systems. Part II deals with the use of chitosan and derivatives in the
formulation and delivery of biopharmaceuticals, and focuses on the
synergistic effects between chitosan and this particular subset of
pharmaceuticals. Part III discusses specific applications of chitosan
and its derivatives for biopharmaceutical use. Finally, Part IV
presents diverse viewpoints on different issues such as regulatory,
manufacturing and toxicological requirements of chitosan and its
derivatives related to the development of biopharmaceutical products,
as well as their patent status, and clinical application and potential.
Topics covered include:
- chemical and technological advances in chitins and chitosans
useful for the formulation of biopharmaceuticals
- physical properties of chitosan and derivatives in sol and gel states
- absorption promotion properties of chitosan and derivatives
- biocompatibility and biodegradation of chitosan and derivatives
- biological and pharmacological activity of chitosan and derivatives
- biological, chemical and physical compatibility of chitosan and biopharmaceuticals
- approaches for functional modification or crosslinking of chitosan
- use of chitosan and derivatives in conventional
biopharmaceutical dosage forms
- manufacture techniques of chitosan-based microparticles and
nanoparticles for biopharmaceuticals
- chitosan and derivatives for biopharmaceutical use: mucoadhesive properties
- chitosan-based systems for mucosal delivery of biopharmaceuticals
- chitosan-based delivery systems for mucosal vaccination
- chitosan-based nanoparticulates for oral delivery of biopharmaceuticals
- chitosan-based systems for ocular delivery of biopharmaceuticals
- chemical modification of chitosan for delivery of DNA and siRNA
- target-specific chitosan-based nanoparticle systems for nucleic
acid delivery
- functional PEGylated chitosan systems for biopharmaceuticals
- stimuli-sensitive chitosan-based systems for biopharmaceuticals
- chitosan copolymers for biopharmaceuticals
- application of chitosan for anti-cancer biopharmaceutical delivery
- chitosan-based biopharmaceuticals scaffolds in tissue
engineering and regenerative medicine
- wound healing properties of chitosan and its use in wound
dressing biopharmaceuticals
- toxicological properties of chitosan and derivatives for
biopharmaceutical applications
- regulatory status of chitosan and derivatives
- patentability and intellectual property issues
- quality control and good manufacturing practice
- preclinical and clinical use of chitosan and derivatives for biopharmaceuticals
Chitosan-Based Systems for Biopharmaceuticals is an important
compendium of fundamental concepts, practical tools and applications
of chitosan-based biopharmaceuticals for researchers in academia and
industry working in drug formulation and delivery, biopharmaceuticals,
medicinal chemistry, pharmacy, bioengineering and new materials
development.
Bruno Sarmento, Department of Pharmaceutical
Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal
& CICS, Department of Pharmaceutical Sciences, Instituto Superior
de Ciências da Saúde-Norte, Gandra, Portugal
José das Neves, Department of Pharmaceutical Technology,
Faculty of Pharmacy, University of Porto, Porto, Portugal
