Book description
Compiles current tested and proven approaches to synthesize novel
nucleoside analogues
Featuring contributions from leading synthetic chemists from around
the world, this book brings together and describes tested and proven
approaches for the chemical synthesis of common families of nucleoside
analogues. Readers will learn to create new nucleoside analogues with
desired therapeutic properties by using a variety of methods to
chemically modify natural nucleosides, including:
- Changes to the heterocyclic base
- Modification of substituents at the sugar ring
- Replacement of the furanose ring by a different carbo- or
heterocyclic ring
- Introduction of conformational restrictions
- Synthesis of enantiomers
- Preparation of hydrolitically stable C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers all the major
classes of nucleosides, including pronucleotides, C-nucleosides,
carbanucleosides, and PNA monomers which have shown great promise as
starting points for the synthesis of nucleoside analogues. The book
also includes experimental procedures for key reactions related to the
synthesis of nucleoside analogues, providing a valuable tool for the
preparation of a number of different compounds.
Throughout the book, chemical schemes and figures help readers better
understand the chemical structures of nucleoside analogues and the
methods used to synthesize them. Extensive references serve as a
gateway to the growing body of original research studies and reviews
in the field.
Synthetically modified nucleosides have proven their value as
therapeutic drugs, in particular as antiviral and antitumor agents.
However, many of these nucleoside analogues have undesirable side
effects. With Chemical Synthesis of Nucleoside Analogues as
their guide, researchers have a new tool for synthesizing a new
generation of nucleoside analogues that can be used as therapeutic
drugs with fewer unwanted side effects.
PEDRO MERINO, PhD, is the Director of the Department of
Synthesis and Structure of Biomolecules of the Institute of Chemical
Synthesis and Homogenous Catalysis at the University of Zaragoza. Dr.
Merino has authored more than 200 publications, including several
reviews and book chapters. His research spans asymmetric synthesis,
target-oriented synthesis, organometallic chemistry, and asymmetric
metal-assisted and organic catalysis. Recently, he has been
investigating the use of computational chemistry to better understand
reaction mechanisms.
