Book description
Many newly proposed drugs suffer from poor water solubility, thus
presenting major hurdles in the design of suitable formulations for
administration to patients. Consequently, the development
of
techniques and materials to overcome these hurdles is a major
area of research in pharmaceutical companies.
Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a
comprehensive overview of currently used formulation strategies for
hydrophobic drugs, including liposome formulation, cyclodextrin drug
carriers, solid lipid nanoparticles, polymeric drug encapsulation
delivery systems, self-microemulsifying drug delivery systems,
nanocrystals, hydrosol colloidal dispersions, microemulsions, solid
dispersions, cosolvent use, dendrimers, polymer- drug conjugates,
polymeric micelles, and mesoporous silica nanoparticles. For each
approach the book discusses the main instrumentation, operation
principles and theoretical background, with a focus on
critical
formulation features and clinical studies. Finally, the
book includes some recent and novel applications, scale-up
considerations and regulatory issues.
Drug Delivery Strategies for Poorly Water-Soluble Drugs is an
essential multidisciplinary guide to this important area of drug
formulation for researchers in industry and academia working in
drug
delivery, polymers and biomaterials.
