Book description
Innovative approach to drug design that's more likely to result in
an approvable drug product
Retrometabolic drug design incorporates two distinct drug design
approaches to obtain soft drugs and chemical delivery systems,
respectively. Combining fundamentals with practical step-by-step
examples, Retrometabolic Drug Design and Targeting gives
readers the tools they need to take full advantage of retrometabolic
approaches in order to develop safe and effective targeted drug
therapies. The authors, both pioneers in the fields of soft drugs and
retrometabolic drug design, offer valuable ideas, approaches, and
solutions to a broad range of challenges in drug design, optimization,
stability, side effects, and toxicity.
Retrometabolic Drug Design and Targeting begins with an
introductory chapter that explores new drugs and medical progress as
well as the challenges of today's drug discovery. Next, it discusses:
- Basic concepts of the mechanisms of drug action
- Drug discovery and development processes
- Retrometabolic drug design
- Soft drugs
- Chemical delivery systems
Inside the book, readers will find examples from different
pharmacological areas detailing the rationale for each drug design.
These examples set forth the relevant pharmacokinetic and
pharmacodynamic properties of the new therapeutic agents, comparing
these properties to those of other compounds used for the same
therapeutic purpose. In addition, the authors review dedicated
computer programs that are available to support and streamline
retrometabolic drug design efforts.
Retrometabolic Drug Design and Targeting is recommended for all
drug researchers interested in employing this newly tested and proven
approach to developing safe and effective drugs.
NICHOLAS BODOR is Graduate Research Professor Emeritus (active)
at the University of Florida. He has over 500 publications and 220
patents to his credit. His many awards include the Florida Scientist
of the Year, the Volweiler Award, the Distinguished Pharmaceutical
Scientist Award, the Fabinyi Prize, and the Commander's Cross of the
Order of Merit of Hungary. He holds numerous honorary doctor degrees.
He was elected to the Hungarian Academy of Sciences and inducted to
the ACS Medicinal Chemistry Hall of Fame.
PETER BUCHWALD is Assistant Professor in the Department of
Molecular and Cellular Pharmacology and Director of Drug Discovery for
the Diabetes Research Institute at the University of Miami. He is the
author of nine book chapters and eighty-six peer-reviewed
publications.
