Book description
The first thorough review of cyclooxygenase inhibitors, including
their toxicity mechanisms and toxicopathological risks
Cyclooxygenases (COXs) are enzymes responsible for the formation of
an important class of biological mediators called prostanoids.
Prostanoids such as prostaglandins mediate inflammatory and
anaphylactic reactions. For those suffering from inflammation and
pain, the pharmacological inhibition of COXs, with non-steroidal
anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide
relief. Yet the use of NSAIDs can trigger toxicological effects as
well, leading to potential health risks.
Comparative Pathophysiology and Toxicology of Cyclooxygenases
provides a comprehensive overview of how COX inhibitors affect various
bodily systems, specifically the toxicity mechanisms triggered when
the COX enzyme is inhibited. The book provides an introduction to the
discovery of cyclooxygenases, their use as therapeutic agents, as well
as an historical perspective. Shedding light on the differences in
expression, pathophysiology, and toxicology of COX inhibitors across
species, the book offers a systematic examination of the effects and
pathophysiology of COX inhibitors and their mechanisms of toxicity,
beginning with the GI tract. Subsequent chapters cover:
- The pathophysiology of COX inhibition on bone, tendon, and
ligament healing
- COX inhibitors and renal system pathophysiology and mechanisms of toxicity
- The pathophysiologic role of COX inhibition in the ocular system
- COX inhibition and the respiratory and cardiovascular systems
The book also sheds light on the latest research devoted to
developing COX inhibitors with no adverse side-effects. The first book
to offer a thorough comparative look at the toxicological effects of
COX inhibitors throughout the body, this invaluable resource will help
advance the research and development of safer and more effective COX drugs.
ZAHER A. RADI is a Research Fellow and Toxicologic Anatomic
Pathologist in Drug Safety R&D at Pfizer Worldwide Research &
Development. He has published over fifty-five research papers and
review articles, in addition to book chapters and numerous abstracts
and presentations.
