Book description
All the latest tools needed to plan and perform the synthesis of
complex bioactive molecules
Focusing on organic, organometallic, and bio-oriented processes, this
book explores the impact and use of the latest synthetic tools for the
synthesis of complex biologically active compounds. Readers will
discover step by step how these synthetic tools have provided new,
elegant solutions to many synthetic puzzles. Moreover, they will
discover innovative methods that make it possible to control the exact
connectivity of atoms within a molecule in order to set precise
three-dimensional arrangements.
Modern Tools for the Synthesis of Complex Bioactive Molecules
features sixteen chapters, each one written by one or more leading
experts in organic synthesis from around the world. It covers a broad
range of topics that enable readers to take advantage of the latest
methods for synthesizing complex molecules, including:
- Modern catalysis, emphasizing key transformations such as C-H
functionalizations, cross-couplings, gold-catalyzed reactions,
metathesis-based syntheses, and asymmetric organocatalysis
- Eco-compatible transformations, including rearrangements and
domino reactions
- Tools for the synthesis of carbohydrates and alkaloids
- New techniques, including the use of fluorous tags and
engineered biosynthesis
The last two chapters explore target- and diversity-oriented organic
synthesis as well as the use of DNA-based asymmetric catalysis, which
are all promising tools for the successful synthesis of complex
bioactive molecules.
Modern Tools for the Synthesis of Complex Bioactive Molecules
is ideal for students and researchers who need to plan and perform the
synthesis of complex molecules as efficiently as possible. The book's
expert advice will help these readers quickly resolve a broad range of
problems that can arise in organic syntheses.
JANINE COSSY graduated from the University of Reims working
under the supervision of Prof. Jean-Pierre Pète. After a postdoctoral
stay with Prof. Barry Trost (1980-1982) at the University of
Wisconsin, she returned to Reims where she became Director of Research
of the CNRS in 1990. The same year, she moved to Paris to become
Professor of Organic Chemistry at the Ecole Supérieure de Physique et
de Chimie Industrielles de la Ville de Paris (ESPCI ParisTech). She
has published over 380 articles and filed thirteen patents in the
field of synthetic organic chemistry and natural product synthesis.
She is Associate Editor at Organic Letters since 2005.
STELLIOS ARSENIYADIS was born in Greece in 1975. He studied
chemistry at the Université Paris XI and received his PhD in 2002 from
the Université Louis Pasteur (Strasbourg, France) working under the
guidance of Dr. Charles Mioskowski. In 2001, he joined Rhodia ChiRex
(Boston, USA) for an eighteen-month internship in collaboration with
Prof. Stephen L. Buchwald (MIT, USA). He then spent a year as a
postdoctoral fellow at Imperial College London (UK) working under the
supervision of Prof. Alan C. Spivey, after which he joined Prof. K. C.
Nicolaou's group at The Scripps Research Institute (La Jolla, USA) for
an additional postdoc. In 2005, he was appointed by the CNRS as Chargé
de Recherche in Prof. Janine Cossy's group. His research interests
include the development of new synthetic tools and their application
to the total synthesis of complex natural products.
