Antibacterial Agents is an essential guide to this important
class of chemotherapeutic drugs. Compounds are organised according to
their target, which helps the reader understand the mechanism of
action of these drugs and how resistance can arise. The book uses an
integrated “lab-to-clinic” approach which covers drug discovery,
source or synthesis, mode of action, mechanisms of resistance,
clinical aspects (including links to current guidelines, significant
drug interactions, cautions and contraindications), prodrugs and
future improvements. Agents covered include:
• agents targeting DNA - quinolone, rifamycin, and nitroimidazole
antibacterial agents
• agents targeting metabolic processes -
sulfonamide antibacterial agents and trimethoprim
• agents
targeting protein synthesis - aminoglycoside, macrolide and
tetracycline antibiotics, chloramphenicol, and oxazolidinones
• agents targeting cell wall synthesis - β-Lactam and
glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of
students of pharmacy, pharmacology, pharmaceutical sciences, drug
design/discovery, and medicinal chemistry, and as a bench reference
for pharmacists and pharmaceutical researchers in academia and industry.
