Book description
The Pauson-Khand reaction is an important reaction in the field of
organic chemistry. It involves the transition-metal catalysed
cycloaddition of an alkyne, an alkene and carbon monoxide, to produce
cyclopentenones. The importance of this reaction originates from its
high value in transforming simple components into the synthetically
useful cyclopentenone unit, in which a high degree of molecular
complexity can be achieved in a single step, with impressive
stereochemical and regiochemical control.
The Pauson-Khand Reaction investigates the nature and many
variations of this reaction.
Topics covered include:
- the mechanisms of Pauson Khand-type reactions
- non chiral intramolecular and intermolecular versions of Pauson
Khand reactions
- asymmetric Pauson Khand reaction using chiral auxiliaries
- the enantioselective Pauson Khand reaction
- Pauson Khand reactions catalysed by metals other than cobalt
- unconventional Pauson Khand reactions
- the Pauson Khand reaction in total synthesis
Presenting a comprehensive overview of this fundamental reaction,
The Pauson-Khand Reaction will find a place on the
bookshelves of any organic or organometallic chemist.
