Book description
Hot-melt extrusion (HME) - melting a substance and forcing it through
an orifice under controlled conditions to form a new material - is an
emerging processing technology in the pharmaceutical industry for the
preparation of various dosage forms and drug delivery systems, for
example granules and sustained release tablets.
Hot-Melt Extrusion: Pharmaceutical Applications covers the main
instrumentation, operation principles and theoretical background of
HME. It then focuses on HME drug delivery systems, dosage forms and
clinical studies (including pharmacokinetics and bioavailability) of
HME products. Finally, the book includes some recent and novel HME
applications, scale -up considerations and regulatory issues. Topics
covered include:
- principles and die design of single screw extrusion
- twin screw extrusion techniques and practices in the laboratory
and on production scale
- HME developments for the pharmaceutical industry
- solubility parameters for prediction of drug/polymer miscibility
in HME formulations
- the influence of plasticizers in HME
- applications of polymethacrylate polymers in HME
- HME of ethylcellulose, hypromellose, and polyethylene oxide
- bioadhesion properties of polymeric films produced by HME
- taste masking using HME
- clinical studies, bioavailability and pharmacokinetics of HME products
- injection moulding and HME processing for pharmaceutical materials
- laminar dispersive & distributive mixing with dissolution and
applications to HME
- technological considerations related to scale-up of HME processes
- devices and implant systems by HME
- an FDA perspective on HME product and process understanding
- improved process understanding and control of an HME process with
near-infrared spectroscopy
Hot-Melt Extrusion: Pharmaceutical Applications is an essential
multidisciplinary guide to the emerging pharmaceutical uses of this
processing technology for researchers in academia and industry working
in drug formulation and delivery, pharmaceutical engineering and
processing, and polymers and materials science.
This is the first book from our brand new series Advances in
Pharmaceutical Technology.
Find
out more about the series here.
Dr. Dionysios Douroumis
, Senior Lecturer, School of Science, University of Greenwich, UK
After completing his postgraduate studies Dr Douroumis worked as a
postdoctoral fellow at the Friedrich - Schiller University of Jena in
the Department of Pharmacy, and later as a Senior Scientist at Phoqus
Pharmaceutical plc, tasked with the development of sustained/pulsatile
release formulations, orally disintegrating tablets and taste masking of
bitter drugs; some of these studies were in collaboration with Evonik
GmbH in Darmstadt, Germany. He is currently Senior Lecture at the in the
University of Greenwich School of Science where he coordinates the
course for the MSc Pharmaceutical Science Programme (350 students per
annum) and is also a tutor for undergraduate studies in Pharmaceutical
Sciences.
