Book description
Explains how to perform and analyze the results of the latest
physicochemical methods
With this book as their guide, readers have access to all the current
information needed to thoroughly investigate and accurately determine
a compound's pharmaceutical properties and their effects on drug
absorption. The book emphasizes oral absorption, explaining all the
physicochemical methods used today to analyze drug candidates.
Moreover, the author provides expert guidance to help readers analyze
the results of their studies in order to select the most promising
drug candidates.
This Second Edition has been thoroughly updated and revised,
incorporating all the latest research findings, methods, and
resources, including:
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Descriptions and applications of new PAMPA models, drawing on
more than thirty papers published by the author's research group
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Two new chapters examining permeability and Caco-2/MDCK and
permeability and the blood-brain barrier
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Expanded information and methods to support pKa determination
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New examples explaining the treatment of practically insoluble
test compounds
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Additional case studies demonstrating the use of the latest
physicochemical techniques
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New, revised, and expanded database tables throughout the book
Well over 200 drawings help readers better understand difficult
concepts and provide a visual guide to complex procedures. In
addition, over 800 references serve as a gateway to the primary
literature in the field, facilitating further research into all the
topics covered in the book.
This Second Edition is recommended as a reference for
researchers in pharmaceutical R&D as well as in agrochemical,
environmental, and other related areas of research. It is also
recommended as a supplemental text for graduate courses in pharmaceutics.
ALEX AVDEEF, PhD, is the founder of in-ADME Research. He has
more than thirty years of experience in chemical instrumentation and
software development. Internationally recognized as an authority in
the field of solution chemistry, Dr. Avdeef has an extensive list of
scholarly publications to his credit.
