Book description
This book is a comprehensive and up-to-date review and evaluation of
the contemporary status of telomerase research. Chapters in this volume
cover the basic structure, mechanisms, and diversity of the essential
and regulatory subunits of telomerase. Other topics include telomerase
biogenesis, transcriptional and post-translational regulation,
off-telomere functions of telomerase and the role of telomerase in
cellular senescence, aging and cancer. Its relationship to
retrotransposons, a class of mobile genetic elements that shares
similarities with telomerase and serves as telomeres in selected
organisms, are also reviewed.
NEAL F. LUE, MD, PhD, is Professor in the Department of
Microbiology and Immunology at Weill Cornell Medical College. He
received his BS from Johns Hopkins University and his MD and PhD from
Stanford University. His laboratory studies the structures and
mechanisms of the telomere and telomerase complexes in a variety of
fungal model systems.
CHANTAL AUTEXIER, PhD, is Professor in the Department of
Anatomy and Cell Biology and the Department of Medicine at McGill
University. She received her BSc from Concordia University and her PhD
from McGill University. Her laboratory studies the mechanisms that
regulate telomerase and telomere functions in mammalian cells, and
evaluates the principles of anticancer strategies that target these
mechanisms.
