Book description
This timely reference discusses mass spectrometry in drug metabolism
and pharmacokinetic studies. With contributions by professionals from
the pharmaceutical industry, this book begins with a review of current
mass spectrometry techniques and applications, followed by discussions
of various methods for using MS in drug metabolism studies and
pharmacokinetics. Highlighting the critical importance of ADME studies
for understanding how a drug is absorbed, distributed, metabolized, and
excreted by the body, the book s focuses on the use of LC/MS and
MALDI-MS. This is a valuable reference for scientists in the
pharmaceutical industry, medicine, academia, and even those working in
homeland defense.
Ragu Ramanathan
received a B. Sc. in Chemistry from the University of Southern
Mississippi and a Ph. D. in Physical Chemistry/Mass Spectrometry from
the University of Florida. His graduate research focused on coupling of
electrospray ionization (ESI) to Fourier transform ion cyclotron
resonance (FTICR) mass spectrometer. After spending three years as a
postdoctoral research fellow with Professor Michael L. Gross at the
Washington University, St. Louis, Missouri, Dr. Ramanathan managed the
Center for Advanced Mass Spectrometry at the Analytical Bio-Chemistry
Laboratories, Columbia, Missouri. In 1998, Dr. Ramanathan joined
Schering-Plough Research Institute's (SPRI) Drug Metabolism and
Pharmacokinetics (DMPK) Department and completed his tenure as a senior
principal scientist in 2008. While at SPRI, Dr. Ramanathan was involved
in the application of LC-MS for profiling and characterization of
metabolites of drug candidates in the preclinical development and
clinical stages. Dr. Ramanathan was with Pfizer Global Research and
Development from 1999 to 2002 as a group leader of the Ann Arbor site
biotransformation group. Dr. Ramanathan is currently an associate
director at the Bristol-Myers Squibb, Co. and is responsible for
elucidating biotransformation pathways of development drug candidates.
Dr. Ramanathan's accomplishments include 35 peer-reviewed papers, 10
book chapters, and over 60 oral/poster presentations. He also served as
a chairperson for the North Jersey ACS Mass Spectrometry Discussion
Group and as a chairman for DMPK sessions of the American Society for
Mass Spectrometry and Eastern Analytical Symposium meetings.
