Book description
With its clear, straightforward presentation, this text enables you to
grasp all the fundamental concepts of pharmacokinetics and
pharmacodynamics. This will allow you to understand the time course of
drug response and dosing regimen design. Clinical models for
concentration and response are described and built from the basic
concepts presented in earlier chapters. Your understanding of the
material will be enhanced by guided computer exercises conducted on a
companion website. Simulations will allow you to visualize drug
behavior, experiment with different dosing regimens, and observe the
influence of patient characteristics and model parameters. This makes
the book ideal for self-study.
By including clinical models of agonism, indirect drug effects,
tolerance, signal transduction, and disease progression, author Sara
Rosenbaum has created a work that stands out among introductory-level
textbooks in this area. You'll find several features throughout the
text to help you better understand and apply key concepts:
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Three fictitious drugs are used throughout the text to
progressively illustrate the development and application of
pharmacokinetic and pharmacodynamic principles
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Exercises at the end of each chapter reinforce the concepts and
provide the opportunity to perform and solve common dosing problems
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Detailed instructions let you create custom Excel worksheets to
perform simple pharmacokinetic analyses
Because this is an introductory textbook, the material is presented
as simply as possible. As a result, you'll find it easy to gain an
accurate, working knowledge of all the core principles, apply them to
optimize dosing regimens, and evaluate the clinical pharmacokinetic
and pharmacodynamic literature.
Sara E. Rosenbaum, PhD, is Professor of Biomedical
and Pharmaceutical Sciences at the University of Rhode Island, where
she teaches courses in pharmacokinetics. She is also the former
editor-in-chief of Clinical Research and Regulatory Affairs.
Dr. Rosenbaum's research interests concentrate on the development and
application of pharmacokinetic and pharmacodynamic models that build
our understanding of the drug dose-response relationship.
