Book description
A comprehensive guide to cutting-edge tools in ADME research
The last decade has seen tremendous progress in the development of
analytical techniques such as mass spectrometry and molecular biology
tools, resulting in important advances in drug discovery, particularly
in the area of absorption, distribution, metabolism, and excretion
(ADME).
ADME-Enabling Technologies in Drug Design and Development focuses on
the current state of the art in the field, presenting a comprehensive
review of the latest tools for generating ADME data in drug discovery.
It examines the broadest possible range of available technologies,
giving readers the information they need to choose the right tool for
a given application, a key requisite for obtaining favorable results
in a timely fashion for regulatory filings. With over thirty
contributed chapters by an international team of experts, the book provides:
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A thorough examination of current tools, covering both
electronic/mechanical technologies and biologically based ones
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Coverage of applications for each technology, including key
parameters, optimal conditions for intended results, protocols,
and case studies
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Detailed discussion of emerging tools and techniques, from stem
cells and genetically modified animal models to imaging technologies
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Numerous figures and diagrams throughout the text
Scientists and researchers in drug metabolism, pharmacology,
medicinal chemistry, pharmaceutics, toxicology, and bioanalytical
science will find ADME-Enabling Technologies in Drug Design and
Development an invaluable guide to the entire drug development
process, from discovery to regulatory issues.
Donglu Zhang, PhD, is a Principal Scientist in Pharmaceutical
Candidate Optimization at Bristol-Myers Squibb in Princeton, New
Jersey. He has published seventy peer-reviewed articles, codiscovered
the Mass Defect Filtering technique, and coedited two books.
Sekhar Surapaneni, PhD, is Director, DMPK, at Celgene
Corporation in New Jersey. He has published extensively in
peer-reviewed journals and is a member of ISSX and ACS.
