Book description
The book that highlights mass spectrometry and its application in
characterizing proteins and peptides in drug discovery
An instrumental analytical method for quantifying the mass and
characterization of various samples from small molecules to large
proteins, mass spectrometry (MS) has become one of the most widely
used techniques for studying proteins and peptides over the last
decade. Bringing together the work of experts in academia and
industry, Protein and Peptide Mass Spectrometry in Drug
Discovery highlights current analytical approaches, industry
practices, and modern strategies for the characterization of both
peptides and proteins in drug discovery.
Illustrating the critical role MS technology plays in characterizing
target proteins and protein products, the methods used, ion mobility,
and the use of microwave radiation to speed proteolysis, the book also
covers important emerging applications for neuroproteomics and
antigenic peptides. Placing an emphasis on the pharmaceutical
industry, the book stresses practice and applications, presenting
real-world examples covering the most recent advances in mass
spectrometry, and providing an invaluable resource for pharmaceutical
scientists in industry and academia, analytical and bioanalytical
chemists, and researchers in protein science and proteomics.
Michael L. Gross, PhD, is a Professor in the
Departments of Chemistry, Medicine, and Immunology at Washington
University in St. Louis. He is also Principal Investigator at the
National Institutes of Health (NIH) Research Resource in Mass Spectrometry.
Guodong Chen, PhD, is Principal Scientist in Bioanalytical and
Discovery Analytical Sciences at Bristol-Myers Squibb in Princeton,
New Jersey. He heads a mass spectrometry group in support of drug
discovery as well as development programs in small molecule
pharmaceuticals and biologics.
Birendra N. Pramanik, PhD, was a Distinguished Fellow at
Schering-Plough Research Institute (SPRI), where he directed the
spectroscopy, mass spectrometry, and NMR programs.
