Book description
The one-stop reference to pharmacogenetics and its impact on
pharmaceuticals, therapeutics, and clinical practices
Pharmacogenetics and Individualized Therapy offers thorough coverage
of the study of the genetic determinants of drug response at the
single gene levelÂ-and its impact on pharmaceuticals, therapeutics,
and clinical practice. Providing an overview of the molecular basis of
pharmacogenetics, the book helps readers understand the implications
of genetic variability on pharmacokinetics and pharmacodynamics, as
well as other aspects such as adverse drug reactions. Providing
coverage of specific disease areas, including cardiovascular concerns,
cancer and asthma/COPD, transplantation, and pain medication, the book
also looks at the clinical practices, along with the psychiatric and
ethical issues that have come to dominate conversation about pharmacogenetics.
The technological applications of pharmacogenetics, including
genotyping, drug disposition (metabolism and enzymes), and the impact
of this research on the pharmaceutical industry and regulatory matters
are all addressed in chapters by internationally recognized leaders
from both academia and industry.
Including chapters on specific therapeutic areas and clinical
aspects, Pharmacogenetics and Individualized Therapy helps readers,
whether they're students or researchers, to understand the
implications of genetic variability on pharmacokinetics and
pharmacodynamics.
ANKE-HILSE MAITLAND-van der ZEE, PhD, is Associate Professor of
Pharmacogenetics/Pharmacogenomics at Utrecht University, the
Netherlands.
ANN K. DALY, PhD, is Professor of Pharmacogenetics at Newcastle
University, UK.
