Book description
Covers the vastly expanding subject of oxidative processes mediated
by copper ions within biological systems
Copper-mediated biological oxidations offer a broad range of
fundamentally important and potentially practical chemical processes
that cross many chemical and pharmaceutical disciplines. This newest
volume in the Wiley Series on Reactive Intermediates in
Chemistry and Biology is divided into three logical areas within the
topic of copper/oxygen chemistry- biological systems, theory, and
bioinorganic models and applications-to explore the biosphere for its
highly evolved and thus efficient oxidative transformations in the
discovery of new types of interactions between molecular oxygen and
copper ion. Featuring a diverse collection of subject matter unified
in one complete and comprehensive resource, Copper-Oxygen Chemistry
probes the fundamental aspects of copper coordination chemistry,
synthetic organic chemistry, and biological chemistry to reveal both
the biological and chemical aspects driving the current exciting
research efforts behind copper-oxygen chemistry. In addition,
Copper-Oxygen Chemistry:
-
Addresses the significantly increasing literature on
oxygen-atom insertion and carbon-carbon bond-forming reactions
as well as enantioselective oxidation chemistries
-
Progresses from biological systems to spectroscopy and theory,
and onward to bioinorganic models and applications
-
Covers a wide array of reaction types such as insertion and
dehydrogenation reactions that utilize the cheap, abundant, and
energy-containing O2 molecule
With thorough coverage by prominent authors and researchers shaping
innovations in this growing field, this valuable reference is
essential reading for bioinorganic chemists, as well as organic,
synthetic, and pharmaceutical chemists in academia and industry.
Kenneth D. Karlin is Ira Remsen Professor of
Chemistry at Johns Hopkins University. His bioinorganic research
focuses on coordination chemistry relevant to biological and
environmental processes, involving copper or heme (porphyrin-iron)
complexes. Dr. Karlin's main approach involves synthetic modeling, i.
e., biomimetic chemistry. He is the winner of the prestigious F.
Albert Cotton Award in Synthetic Inorganic Chemistry and the Sierra
Nevada Distinguished Chemist Award, both awarded in 2009.
Shinobu Itoh focuses his current research on chemical modeling
and application of novel active sites in biological systems. He was
formerly an assistant professor at Osaka University, where he worked
on the chemistry of coenzyme PQQ and cofactor TTQ as well as model
compounds of galactose oxidase. In 1994, he was promoted to associate
professor at Osaka University, where he collaborated with Professor
Shunichi Fukuzumi in copper-dioxygen chemistry research. In 1999, he
moved to Osaka City University as a full professor and started
biological studies of dinuclear copper proteins, such as hemocyanin
and tyrosinase. He returned to Osaka University in 2008 and further
expanded his research interests to the design of artificial non-heme
metalloenzymes using genetic engineering.
