Book description
How protein chaperones protect cells from neurodegenerative diseases
Including contributions from leading experts, Protein Chaperones and
Protection from Neurodegenerative Diseases provides an in-depth
exploration of how protein chaperones are involved in shielding cells
from toxic aggregated or misfolded protein states that cause ALS,
Parkinson's, and related diseases.
Examining how different protein chaperones ameliorate the toxicity of
proteins that are known to cause neurodegenerative damage, the book
addresses both research and clinical perspectives on chaperone and
anti-chaperone properties. The intersection of molecular chaperones
and neurodegeneration is an intensely studied area, partly because of
the potential for manipulating the expression of molecular chaperones
to thwart the progression of debilitating diseases, and partly because
of the ever-aging global population.
Discussing the potential to harness the power of protein chaperones,
and future directions for research, discovery, and therapeutics, this
book is essential reading for scientists working in the fields of
biochemistry, molecular medicine, pharmacology and drug discovery,
biotechnology and pharmaceutical companies, advanced students, and
anyone interested in this cutting-edge topic.
Stephan N. Witt is a Professor in the Department of Biochemistry and
Molecular Biology at the Louisiana State University Health Sciences
Center in Shreveport, Louisiana. He obtained his PhD in biophysical
chemistry from the California Institute of Technology.??Dr. Witt is a
member of the editorial board of Cell Stress and Chaperones. He has
served on numerous NIH study sections, has authored over forty
scientific publications, and edited a book on using yeast as a model
for human disease. His research focuses on identifying genes and small
molecules that can be used against Parkinson's disease.
