Book description
The most complete, up-to-date reference on antigen retrieval and immunohistochemistry
An antigen is a substance that prompts the generation of antibodies
and can cause an immune response. The antigen retrieval (AR) technique
is in wide use across the globe, and is a critical technique used in
medical diagnosis of disease, particularly clinical targeted cancer treatment.
Antigen Retrieval Immunohistochemistry Based Research and
Diagnostics discusses several scientific approaches to the
standardization of quantifiable immunohistochemistry (IHC). Based on
the development and application of AR by the editors, this volume
summarizes recent achievements in AR-IHC and analyzes numerous
cutting-edge issues for future research projects.
Featuring contributions from a worldwide group of leading experts and
research scientists in the field, this important work:
- Summarizes the key problems in the four fields of antigen retrieval
- Discusses the advances of AR techniques and their applications
- Provides practical methods and protocols in AR-IHC, such as
extraction of nucleic acids and proteins for molecular analysis,
cell/tissue sample preparation, and standardization and
development of various techniques to meet the future needs
of¿clinical and research molecular analysis
- Encourages further research in AR and IHC, particularly how AR
methods might be employed for improved test performance and the
development of greater reliability and reproducibility of IHC
- Includes an appendix of related laboratory protocols
Antigen Retrieval Immunohistochemistry Based Research and
Diagnostics is intended for clinical pathologists, molecular cell
biologists, basic research scientists, technicians, and graduate
students who undertake tissue/cell morphologic and molecular analysis
and wish to use and extend the power of immunohistochemistry. It is
also pertinent for most biotechnology companies majoring in
development of IHC products.
Wiley Series in Biomedical Engineering and Multi-Disciplinary
Integrated Systems / Kai Chang, Series Editor
Shan-Rong Shi, MD, is professor of clinical
pathology at the Keck School of Medicine of the University of Southern
California. He is the Associate Editor of The Journal of
Histochemistry and cytochemistry, he is on the Editoral Board of
Applied Immunohistochemistry and Molecular Morphology and is also on
the Overseas Editorial Board of the Chinese Journal of Pathology. Dr.
Shi is the ineventor of the antigen retrieval (AR) technique.
Clive R. Taylor, MD, PhD, is Senior Associate Dean, Professor
and Chairman of Pathology at the Keck School of Medicine. Dr. Taylor
is Editor in Chief of Applied Immunohistochemistry and Molecular
Morphology. Dr. Taylor is a world renowned expert in
immunohistochemistry and clinical pathology.
