Book description
The purpose of the book is to introduce platelets, and their functional
role in thrombotic and cardiovascular disease, justifying the relevance
of platelet proteomics research. Focus then shifts to the recent
developments on mass spectrometry (MS)-based proteomics. This chapter
shows potential applications for platelet proteomics not yet carried
out. It includes examples of post-translational modifications (PTMs)
analysis in platelets.
The second part of the book focuses on the main research done so far
on platelet proteomics. This includes general proteome mapping by
non-gel based separation methods (MudPit), analysis of the general
platelet proteome and signaling cascades by gel-based separation
methods (2-DE), sub-proteome analyses (secretome/releasate, membrane
proteins, organelles). Finally, the last section links the platelet
transcriptome and application to disease. This section is highly
relevant and includes chapters on proteomics, transcriptomics,
functional genomics, systems biology, and their applications to
platelet-related diseases.
Dr. Ángel García
is currently a Ramón y Cajal Research Fellow at the Pharmacology
Department, Universidade de Santiago de Compostela, Spain His main
research is the area of platelet proteomics, with special emphasis in
cardiovascular research and platelet signaling studies. He has written
over twenty publications in peer-reviewed journals and has been an
invited lecturer at the Platelets 2010 International Symposium
(Jerusalem, Israel), and the XXII Congress of the International Society
on Thrombosis and Haemostasis, held in Boston, United States, in 2009,
where he chaired a session on novel approaches to understanding platelet
biology. Sr. Garcia was a postdoctoral research associate of the
Proteomics Group at the Oxford Glycobiology Institute, University of
Oxford ((UK), from 2001 to 2005.
Dr. Yotis Senis is currently a British Heart Foundation
Research Fellow at the University of Birmingham, United Kingdom. He is
a senior member of the Birmingham Platelet Group. Dr. Senis' research
interests include the identification of novel platelet surface
glycoproteins and determining their biological and molecular
functions. He is also interested in the functional roles of protein
tyrosine phosphatases in platelets and thrombosis. Dr. Senis has been
an invited lecturer at the 2010 International Symposium (Jerusalem,
Israel) and the Gordon Research Conference on the Cell Biology of
Megakaryocytes and Platelets (Galveston, Texas). He has written over
twenty publications on platelet signaling and thrombosis.
