Book description
This book describes the use of NMR spectroscopy for dealing with
problems of small organic molecule structural elucidation. It features a
significant amount of vital chemical shift and coupling information but
more importantly, it presents sound principles for the selection of the
techniques relevant to the solving of particular types of problem,
whilst stressing the importance of extracting the maximum available
information from the simple 1-D proton experiment and of using this to
plan subsequent experiments. Proton NMR is covered in detail, with a
description of the fundamentals of the technique, the instrumentation
and the data that it provides before going on to discuss optimal solvent
selection and sample preparation. This is followed by a detailed study
of each of the important classes of protons, breaking the spectrum up
into regions (exchangeables, aromatics, heterocyclics, alkenes etc.).
This is followed by consideration of the phenomena that we know can
leave chemists struggling; chiral centres, restricted rotation,
anisotropy, accidental equivalence, non-first-order spectra etc. Having
explained the potential pitfalls that await the unwary, the book then
goes on to devote chapters to the chemical techniques and the most
useful instrumental ones that can be employed to combat them.
A discussion is then presented on carbon-13 NMR, detailing its pros
and cons and showing how it can be used in conjunction with proton NMR
via the pivotal 2-D techniques (HSQC and HMBC) to yield vital
structural information. Some of the more specialist techniques
available are then discussed, i. e. flow NMR, solvent suppression,
Magic Angle Spinning, etc. Other important nuclei are then discussed
and useful data supplied. This is followed by a discussion of the
neglected use of NMR as a tool for quantification and new techniques
for this explained. The book then considers the safety aspects of NMR
spectroscopy, reviewing NMR software for spectral prediction and data
handling and concludes with a set of worked Q&As.
Steve Richards graduated in Chemistry from Bangor
University in 1977 and completed an MSc in Analytical Chemistry at
Bristol in 1979. He joined Glaxo Group Research in 1980 and has worked
in the NMR spectroscopy department ever since. He has run regular
courses in NMR interpretation for new graduates and sandwich students
within GSK since the late 80s.
John Hollerton joined the GSK spectroscopy department in 1980.
Having spent time working with other spectroscopic techniques, he has
been focused on NMR spectroscopy since 1982. He is now the manager
with a staff of thirteen scientists working under his direction. John
has also lectured internationally on the subject on many occasions.
