Book description
Biomarkers for Antioxidant Defense and Oxidative Damage: Principles
and Practical Applications
critically evaluates the basic concepts and methodologies of
conventional biomarkers as well as current state-of-the-art assays for
measuring antioxidant activity/oxidative stress and their practical
applications. . Biomarkers for Antioxidant Defense and Oxidative
Damage: Principles and Practical Applications
will be of a great interest to scientists who are involved in basic
research on oxidation, applied scientists evaluating the effects of
nutraceuticals or pharmaceutical compounds on antioxidant
activity/oxidative stress, and physicians who want to understand the
degree of oxidative damage in patients with certain chronic
diseases.
Discovering sensitive and specific biomarkers for systemic
oxidative damage is essential to understand the role of oxidative
stress in human disease. Once these roles are clearly understood, we
are able to identify novel drug and nutraceutical targets. This volume
goes beyond conventional analytical methods of measuring overall
antioxidant activity and provides insight to the discovery of
biomarkers that reveal information on specific areas of oxidative
stress. Contributed by an international list of experts, Biomarkers
for Antioxidant Defense and Oxidative Damage: Principles and
Practical Applications describes both conventional biomarkers
and recent developments in this area.
Special Features:
- Discusses conventional biomarkers as well as recent advances for
measuring antioxidants and oxidative stress
- Biomarkers for lipid peroxidation: isoprostane,
hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl
species from lipid peroxidation
- Biomarkers for protein oxidation: carbonylation, tyrosine
oxidation, ubiquitin-conjugation
- Biomarkers for DNA oxidative damage: comet assay, hydroxylated
nucleotides, and exocylcic DNA adducts
- Recently developed biomarkers from cutting-edge
technology
Giancarlo Aldini, Ph. D., Department of Pharmaceutical
Sciences "Pietro Pratesi", Università degli Studi di
Milano, Milan, Italy
Kyung-Jin Yeum, Ph. D., Jean Mayer USDA-Human Nutrition
Research Center on Aging, Tufts University, Boston, MA, USA.
Etsuo Niki, Ph. D., , Health Research Institute, National
Institute of Advanced Industrial Science & Technology, Osaka, Japan.
Robert M. Russell, M. D., Office of Dietary Supplements,
National Institutes of Health, 6100 Executive Blvd., Bethesda, MD
20892-7517, USA
