Book description
This book examines the background, industrial context, process,
analytical methodology, and technology of metabolite identification. It
emphasizes the applications of metabolite identification in drug
research. While primarily a textbook, the book also functions as a
comprehensive reference to those in the industry. The authors have
worked closely together and combine complementary backgrounds to bring
technical and cultural awareness to this very important endeavor while
serving to address needs within academia and industry It also contains a
variety of problem sets following specific sections in the text.
MIKE S. LEE, PhD,
is President of Milestone Development Services. His recent work has
involved the development of automated orthogonal control systems for
electrospray ionization. Formerly, Dr. Lee was director of analytical
research and development at Bristol-Myers Squibb (BMS) Pharmaceutical
Research Institute where he led interdisciplinary teams that contributed
to the Food and Drug Administration's approval of Buspar® and Serzone®,
and the accelerated development and approval of Taxol®. In addition, he
has authored over forty scientific papers and issued patents.
MINGSHE ZHU, PhD, is a drug metabolism researcher at
Bristol-Myers Squibb, where he leads a team that investigates
biotransformation in new drug discovery and preclinical drug
metabolism and pharmacokinetics in development. His teams have
provided key metabolism and disposition information for regulatory
approval of Abilify® and NDA submission of Dapagliflozin. Dr. Zhu's
research interests include LC/MS technology, optimization of ADME
properties, metabolic activation, and regulatory drug metabolism. He
has been frequently invited to speak and teach short courses at
conferences/workshops and has coauthored over sixty research articles
and one book.
