Book description
There is a need to explain that generic versions of a drug may not be
manufactured by the same process as brand-name drugs and that the
different processes may have dramatically different environmental
impacts. Two global forces are at odds today-the push for
"greener" processes and the push for lower drug prices. This
book brings this conflict into sharp focus by discussing in detail the
published process chemistry for top-selling small molecule drugs.
Providing insights about process route selection, choice of reagents,
and reaction conditions, Pharmaceutical Process Chemistry for
Synthesis guides process chemists in identifying best processes
for manufacturing these blockbuster drugs as they lose patent
protection. Further, it highlights the strategies and methodology that
might be useful for expediting the process research and development of
the blockbusters of the future.
Written from a refreshingly objective perspective, this book is
essential for process chemists who need to devise practical syntheses
for increasingly complex drugs in a constantly decreasing time frame.
Peter J. Harrington
is the founder of Better Pharma Processes, LLC, a consulting firm
specializing in pharmaceutical process design and development. From
1988-2008, he worked for the Syntex Technology Center, later Roche
Colorado, as a research fellow. Dr. Harrington has more than fifty
patents and research publications, including reviews and abstracts, as
well as the book Transition Metals in Total Synthesis (Wiley).
